Retrosynthesis: Computer says yes

Computer-Assisted Retrosynthesis Based on Molecular Similarity

We demonstrate molecular similarity to be a surprisingly effective metric for proposing and ranking one-step retrosynthetic disconnections based on analogy to precedent reactions. The developed approach mimics the retrosynthetic strategy defined implicitly by a corpus of known reactions without the need to encode any chemical knowledge. Using 40 000 reactions from the patent literature as a kno...

Did We or Didn't We? Louse Genetic Analysis Says Yes

Does banner advertising affect browsing for brands ? clickstream choice model says yes , for some

This paper investigates how exposure to Internet display advertising affects the subsequent choices users make of brand-specific pages to view within a website. Using individual-level clickstream data from a third-party automotive website, we tracked the web pages selected by users as they browsed the site and their exposures to premium placement display ads for different vehicle makes (e.g., F...

Yes, hyperglycaemia is indeed a modifiable cardiac risk factor: so says Mendel.

The presence of diabetes is clearly associated with excess cardiovascular risk. However, much controversy exists over whether current glucose-lowering strategies in type 2 diabetes mellitus in fact reduce cardiovascular event rates. Older data had suggested that lowering blood glucose reduced ischaemic events, but contemporary trials of relatively short duration have challenged the long-held co...

A long-term oxidation barrier for copper nanowires: graphene says yes.

Copper nanowires (Cu NWs) hold great promise for the fabrication of low-cost transparent electrodes. However, the instability of Cu NWs has limited their application into commercial devices. Herein, CVD-grown graphene is transferred onto Cu NW films and the stability of the hybrid films over long time scale under different conditions is investigated systematically. The results reveal that the g...